Evolution of a theory: connective tissue and silicon. Past, present and future of a possible association

Abstract

The history of science serves to understand the evolution of a theory, currently solid, presented difficulties, leaving unknowns for later studies and how these allow to extend the link between that initial theory in relation to general and current aspects. Analyzing the connective tissue, its importance for the original cell theory and how opportunely the chemical composition of the extracellular matrix remained pending investigation, adding the rediscovery of silicon in its trajectory from being toxic to being a potentially beneficial element for human health, are examples of how a science progresses from ambiguous knowledge to multidisciplinary work.