Cannabis medicinal

Silvia Kochen

doi:10.18294/sc.2022.3991

Medical cannabis

Silvia Kochen Physician. Doctor of Medicine, specialist in Neurology. Principal investigator, Consejo Nacional de Investigaciones Científicas y Técnicas. Coordinator, Medicinal Cannabis Network (RACME). Deputy Director, Executing Unit in Neurosciences and Complex Systems (ENyS). Professor, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

Received: 23 February 2022, Accepted: 2 March 2022, Published: 3 March 2022

https://doi.org/10.18294/sc.2022.3991 | PMID: 35900986

Abstract views

2604

Metrics Loading ...

PDF (Español)

Abstract

Health is a human right. In order to guarantee that right, it is fundamental that all activities concerning health in different contexts (clinical, research, teaching) contribute to the construction of an efficient system that promotes excellence, equity, justice, and solidarity. In this issue, we take on alternatives regarding the use of medical cannabis from this perspective. Health research and its contribution to knowledge — in particular with respect to the development of new pharmaceuticals — represents not only a challenge related to technology and production, but also an opportunity for ensuring the autonomy of the health system.

Keywords: Cannabis

Categories: Policies, Healthcare models

Full-text of the article is available for this language: Español.

References

1. Li HL. The origin and use of cannabis in Eastern Asia: linguistic-cultural implications. Economic Botany. 1974;28:293-301.

2. United Nations. Convention for limiting the manufacture and regulating the distribution of narcotic drugs [Internet]. 13 jul 1931 [citado 15 feb 2022]. Disponible en: https://tinyurl.com/37npp9zs.

3. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346:561-564. doi: 10.1038/346561a0.

4. Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992;258(5090):1946-1949. doi: 10.1126/science.1470919.

5. World Health Organization. The health and social effects of nonmedical cannabis use [Internet]. 2016 [citado 15 feb 2022]. Disponible en: https://tinyurl.com/bdcmdnyu.

6. Ley 27350: Uso Medicinal de la Planta de Cannabis y sus derivados [Internet]. 2017 [citado 15 feb 2022]. Disponible en: https://tinyurl.com/ep4xm2ty.

7. Ruhul A, Declan A. Pharmacology of Medical Cannabis. Advance in Experimental Medicine and Biology. 2019;1162:151-165. doi: 10.1007/978-3-030-21737-2_8.

8. Di Marzo V, Piscitelli. F. The Endocannabinoid System and its Modulation by Phytocannabinoids. Neurotherapeutics. 2015;12(4):692-698.

9. Saganuwan A. Comparative therapeutic index, lethal time and safety margin of various toxicants and snake antivenoms using newly derived and old formulas. BMC Research Notes. 2020;13:292. doi: 10.1186/s13104-020-05134-x.

10. Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, et al. Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome. New England Journal of Medicine. 2017;376:2011-2020. doi: 10.1056/NEJMoa1611618.

11. Kochen S, Manin A, Montiel R. Artisanal Cannabis in Young and Adults Patients with Treatment Resistant Epilepsy: Prospective, Observational, Open-Label Study in Argentina. Journal of Neurology and Neurological Disorders. 2018;4(2):202. doi: 10.15744/2454-4981.4.202.

12. Mücke M, Phillips T, Radbruch L, Petzke F, Häuser W. Cannabis based medicines for chronic neuropathic pain in adults. Cochrane Database of Systematic Reviews. 2018;3(3):CD012182. doi: 10.1002/14651858.CD012182.pub2.

13. Babson KA, Sottile J, Morabito D. Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Current Psychiatry Reports. 2017;19(4):23. doi: 10.1007/s11920-017-0775-9.

14. Koppel BS, Brust JCM, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D. Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2014;82(17):1556-1563. doi: 10.1212/WNL.0000000000000363.

15. Whiting PF, Wolff RF, Deshpande S. Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA. 2015;313(24):2456-2473. doi: 10.1001/jama.2015.6358.